Preheat the oven to 350°F (175°C).

Grease a 9x5-inch loaf pan with cooking spray or butter, or line it with parchment paper.

In a large mixing bowl, combine the softened cream cheese, butter, and sugar. Mix with an electric mixer on medium speed until smooth.

Add the eggs, one at a time, mixing well after each addition, then add the vanilla extract and combine.

In a separate bowl, whisk together the flour, baking powder, baking soda, and salt.

Gradually add the dry ingredients to the wet ingredients, mixing just until combined.

Gently fold in the blueberries until evenly distributed.

Pour the batter into the prepared loaf pan and smooth the top.

Bake for 50-60 minutes, or until a toothpick inserted in the center comes out clean.

Allow the bread to cool in the pan for 10 minutes before transferring it to a wire rack to cool completely.